One of our employees got something on their laptop that prevented it from running or updating. The exe wouldn't load at all.
There's a trick around this though, and it worked great. Go into the program folder and rename the exe to something else. Then you'll be able to run it without a problem. I believe there's a different exe for the updates, so you can rename that one too if you need to update it.
If it won't install, rename mbam-setup.exe to something else.
I was surprised when it worked, but it worked like a charm!
Just a note for others here, this sometime may be a sign that malware is trying to prevent anti-malware from doing it's job.
Malware can try disable known anti-malware products, or prevent them from being installed by identifying the anti-malware installer program file name.
Renaming the anti-malware file name can help get around this, but should also be done cautiously.